More for the audio interface then software, but I know I like Samplitude.
I used it to record back when I sequenced everything on my Yamaha ie. 1998-2002.
I need an iterface with analog audio I/O, digital audio I/O, midi I/O and I like the headphones out too.
Don't need many ins and I think I'll only use 4 outs for two sets of speakers.